From a dream I had. Jane and his wife were Immortals in a world where immortality was known to the world. There's some sort of drug for Immortals that suppresses the buzz and I think makes it look like they heal at a normal speed, although they still heal quickly from anything too bad. Mortals *really* prefer for Immortals to take the drug [but why?], and a lot of them do, but any Immortal who's been around for a while is pretty creeped out by the buzz thing. Not sure whether Jane and Mrs. Jane took the drugs before, but he definitely doesn't afterwards.

Maybe the drug makes it possible (though not easy) for them to have children?